Olomoucine is a potent inhibitor of cyclin-dependent kinases (CDKs) and has been shown to have potential therapeutic applications in various diseases. In this article, we will discuss the chemical properties, uses, and production of Olomoucine.
Chemical Properties
Olomoucine is a white to off-white solid with a molecular weight of 298.35 g/mol (CAS No. 101622-51-9). It is a purine derivative that competes for the ATP binding site of CDKs, making it an effective inhibitor of these enzymes.
Biological Activity
Olomoucine has been shown to be a potent inhibitor of several CDKs, including cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), and cdk5/p35 kinase (IC50 = 3 μM). It also inhibits ERK1/MAP kinase (IC50 = 25 μM) and arrests human fibroblasts in the G1 phase.
Production
Olomoucine is produced through a multi-step synthesis involving the reaction of benzylamine with 2-hydroxyethylamine to form the desired purine derivative.
Uses
Olomoucine has potential therapeutic applications in various diseases, including cancer, where it can be used as a chemotherapeutic agent. It may also have applications in other fields, such as agriculture and biotechnology.
Precautions
As with any chemical compound, precautions should be taken when handling Olomoucine to ensure safe working conditions and minimize the risk of accidents or exposure.
Related Search
For more information on Olomoucine, search for keywords such as "Olomoucine", "CDK inhibitor", "cytokinin inhibitor", and "potential therapeutic applications".
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